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J T Hecht Selected Research

Pseudoachondroplasia

10/2008The role of cartilage oligomeric matrix protein (COMP) in skeletal disease.
3/2008Model systems for studying skeletal dysplasias caused by TSP-5/COMP mutations.
3/2003Apoptosis staining in cultured pseudoachondroplasia chondrocytes.
7/2001Calreticulin, PDI, Grp94 and BiP chaperone proteins are associated with retained COMP in pseudoachondroplasia chondrocytes.
1/2001Pseudoachondroplasia and multiple epiphyseal dysplasia: New etiologic developments.
8/2000Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes.

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J T Hecht Research Topics

Disease

6Pseudoachondroplasia
10/2008 - 08/2000
3Exostoses
07/2002 - 03/2000
2Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)
10/2008 - 08/2000
1Cleft Lip (Harelip)
07/2014
1Cleft Palate (Palate, Cleft)
07/2014
1Clubfoot (Talipes Equinovarus)
07/2012
1Rheumatoid Arthritis
10/2008
1Arthritis (Polyarthritis)
10/2008
1Osteoarthritis
10/2008
1Wounds and Injuries (Trauma)
10/2008
1Disease Progression
10/2008

Drug/Important Bio-Agent (IBA)

5Proteins (Proteins, Gene)FDA Link
03/2008 - 08/2000
4Cartilage Oligomeric Matrix ProteinIBA
10/2008 - 08/2000
2Collagen Type IXIBA
03/2008 - 03/2003
2Extracellular Matrix ProteinsIBA
03/2008 - 07/2001
2AlginatesIBA
03/2003 - 07/2001
2CalciumIBA
07/2001 - 08/2000
1Matrix Metalloproteinases (MMPs)IBA
07/2014
1Biological ProductsIBA
07/2014
1OligonucleotidesIBA
07/2012
1Matrilin ProteinsIBA
03/2008
1Glycoproteins (Glycoprotein)IBA
03/2003
1Aggrecans (Aggrecan)IBA
03/2003
1DNA (Deoxyribonucleic Acid)IBA
07/2002
1Heparitin Sulfate (Heparan Sulfate)IBA
07/2002
1CalreticulinIBA
07/2001
1DisulfidesIBA
07/2001
1endoplasmic reticulum glycoprotein p72IBA
07/2001
1Endoplasmic Reticulum Chaperone BiPIBA
07/2001
1glucose-regulated proteinsIBA
07/2001
1Mutant Proteins (Protein, Mutant)IBA
07/2001
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
02/2001
1Actins (F Actin)IBA
03/2000